Endocrine Abstracts

Introduction: The diagnosis of Cushing’s syndrome (CS) requires a screening test of high sensitivity, followed by biochemical evaluation aiming to identify the aetiology of hypercortisolism. The high-dose dexamethasone suppression test (HDDST) with the corticotropin-releasing hormone (CRH) test is commonly used for the differential diagnosis of ACTH-depended Cushing’s syndrome. However, the diagnostic utility of the HDDST has been questioned.Ai...

Introduction: Cushing’s disease (CD) is a rare condition, associated with significant morbidities and potentially fatal, if untreated.Objective: To assess the long-term morbidities in a large series of patients with CD during a prolonged follow-up period.Patients and methods: All subjects with CD who presented/followed-up in our Department between 01/1967 and 06/2009 were studied. All information was collected as documented in...

Cushing’s disease (CD) is a rare condition, associated with significant morbidities.The long-term morbidities in a series of patients with CD who presented in two tertiary referral centres between 01/1967-06/2009 were assessed. All information was collected as documented in the records of the patients.224 patients were identified (174 females) with median age at diagnosis 39 years (range 10–76 (females 38 (12–72) &#1...

Background: Cabergoline is effective in achieving normoprolactinaemia and tumour shrinkage in about 70% of patients with macroprolactinoma. Only a few studies have followed-up the adenoma shrinkage for periods >2 years;the need for continuing imaging thereafter is not certain.Aim: To evaluate tumour volume changes in patients with macroprolactinoma responsive to cabergoline during a long follow-up period.Patients and methods: M...